Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells

Berberine has been used for the adjuvant treatment of type 2 diabetes mellitus, hyperlipidemia (high levels fats), and hypertension blood pressure). Also, it different effects on diarrhea, inflammation, cancer. Berberine, is a profoundly common compound in Berberis species. Although cretica one species, unknown whether anti-diabetic yet. synergistic various compounds together with berberin or similar chemical forms berberine within species can lead to find new agents. The aim this study investigate possible drug potential extract containing and, its signaling pathways Rat Insulinoma (INS-1E) cells. According our results, anti-apoptotic INS-1E cells decreasing expression p53, p38 Bax genes. Suppressive plant extracts apoptotic signalling β show that contents have diabetes.